{"id":3862,"date":"2025-08-04T14:34:42","date_gmt":"2025-08-04T14:34:42","guid":{"rendered":"https:\/\/cms.core-way.de\/?p=3862"},"modified":"2025-09-01T15:09:04","modified_gmt":"2025-09-01T15:09:04","slug":"treatment-approaches-for-crohns-disease-based-on-the-s3-guidelines","status":"publish","type":"post","link":"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/","title":{"rendered":"Therapeutic approaches for Crohn's disease based on the S3 guidelines\u00a0"},"content":{"rendered":"<p>The treatment of chronic inflammatory bowel disease is difficult and depends on the individual patient. <strong>Severity of the disease<\/strong> from. Crohn's disease and <a href=\"https:\/\/cms.core-way.de\/en\/ulcerative-colitis-therapy\/\">Ulcerative colitis<\/a> are two of the most widespread chronic inflammatory bowel diseases. The disease, Crohn's disease, can affect the entire gastrointestinal tract, i.e. it can begin in the area of the esophagus and extend to the anus. A distinction is made between patients in whom the upper part of the gastrointestinal tract is affected and those in whom the lower part of the digestive system is affected. The upper area includes the esophagus up to the upper part of the small intestine. In the lower area, the small and large intestines are primarily affected. Accordingly, the treatment approaches for Crohn's disease must be different from other chronic inflammatory bowel diseases (IBD).<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/cms.core-way.de\/wp-content\/uploads\/2024\/05\/qtq80-uI9kSh-1024x683.jpeg\" alt=\"A stethoscope lying on a blue-tinted recording of ECG waves. The image symbolizes therapeutic approaches for Crohn&#039;s disease. The article deals with approaches for the treatment of Crohn&#039;s disease based on the S3 guidelines.\" class=\"wp-image-1203\" srcset=\"https:\/\/cms.core-way.de\/wp-content\/uploads\/2024\/05\/qtq80-uI9kSh-1024x683.jpeg 1024w, https:\/\/cms.core-way.de\/wp-content\/uploads\/2024\/05\/qtq80-uI9kSh-300x200.jpeg 300w, https:\/\/cms.core-way.de\/wp-content\/uploads\/2024\/05\/qtq80-uI9kSh-768x512.jpeg 768w, https:\/\/cms.core-way.de\/wp-content\/uploads\/2024\/05\/qtq80-uI9kSh-1536x1024.jpeg 1536w, https:\/\/cms.core-way.de\/wp-content\/uploads\/2024\/05\/qtq80-uI9kSh-2048x1365.jpeg 2048w, https:\/\/cms.core-way.de\/wp-content\/uploads\/2024\/05\/qtq80-uI9kSh-540x360.jpeg 540w, https:\/\/cms.core-way.de\/wp-content\/uploads\/2024\/05\/qtq80-uI9kSh-1080x720.jpeg 1080w, https:\/\/cms.core-way.de\/wp-content\/uploads\/2024\/05\/qtq80-uI9kSh-1980x1320.jpeg 1980w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>The article deals with the different degrees of severity of the disease and how it can be treated. It focuses on the <strong>S3 guidelines for Crohn's disease<\/strong> supported. All information can be found there in more detail.&nbsp;<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-198ee583\"><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Therapieziele_bei_Morbus_Crohn\" >Therapy goals for Crohn's disease<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Schweregrade_der_Erkrankung_und_deren_Therapieansatze_bei_Morbus_Crohn\" >Severity of the disease and treatment approaches for Crohn's disease<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Das_beeinflusst_deinen_individuelle_Morbus_Crohn_Therapie\" >This influences your individual Crohn's disease therapy:<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Milder_Krankheitsschub\" >Mild relapse<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Therapieansatz_bei_Morbus_Crohn_mit_milden_bis_moderaten_Schuben\" >Therapeutic approach for Crohn's disease with mild to moderate relapses<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Moderater_bis_hoher_Krankheitsschub\" >Moderate to high disease severity<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Das_kannst_du_tun_bei_einem_Krankheitsschub_im_oberen_Magen-Darm-Trakt\" >What you can do if you have a flare-up in the upper gastrointestinal tract<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Moderater_bis_hoher_Krankheitsschub-2\" >Moderate to high disease severity<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Therapieansatze_bei_Morbus_Crohn_mit_Fistelbildung\" >Therapeutic approaches for Crohn's disease with fistula formation<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Remissionserhalt\" >Maintenance of remission<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Das_beeinflusst_deine_Remission\" >This influences your remission<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#_Remissionserhalt\" >&nbsp;Maintenance of remission<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Neue_Therapieansatze_bei_Morbus_Crohn\" >New therapeutic approaches for Crohn's disease<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Therapiemoglichkeiten_in_der_Schwangerschaft\" >Therapy options during pregnancy<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Fazit_%E2%80%93_Was_bedeutet_das_fur_dich_als_Patient_in\" >Conclusion - What does this mean for you as a patient?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#_FAQ_%E2%80%93_Haufige_Fragen_zur_MC-Therapie\" >&nbsp;FAQ - Frequently asked questions about MC therapy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/cms.core-way.de\/en\/therapieansaetze-bei-morbus-crohn-auf-grundlage-der-s3-leitlinien\/#Quellen\" >Sources<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Therapieziele_bei_Morbus_Crohn\"><\/span>Therapy goals for Crohn's disease<span class=\"ez-toc-section-end\"><\/span><\/h2><\/div>\n\n\n\n<p>As already established in 2015, the primary treatment goal for a diagnosis of Crohn's disease is the <strong>Mucosa healing<\/strong>. The inner intestinal mucosa is referred to as the mucosa. It appears in the form of protrusions. In Crohn's disease, the mucosa is damaged at various points in the gastrointestinal tract. In contrast to ulcerative colitis, it is not only the upper layers that are damaged, but also<strong> deeper layers<\/strong>such as the connective tissue or the muscle layer.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"515\" height=\"297\" src=\"https:\/\/cms.core-way.de\/wp-content\/uploads\/2025\/08\/w-und-b-neu.jpg\" alt=\"\" class=\"wp-image-3865\" srcset=\"https:\/\/cms.core-way.de\/wp-content\/uploads\/2025\/08\/w-und-b-neu.jpg 515w, https:\/\/cms.core-way.de\/wp-content\/uploads\/2025\/08\/w-und-b-neu-300x173.jpg 300w\" sizes=\"auto, (max-width: 515px) 100vw, 515px\" \/><\/figure>\n\n\n\n<p>The image shows where the intestinal mucosa becomes inflamed in Crohn's disease. Image source: W&amp;B\/J\u00f6rg Neisel<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"495\" height=\"309\" src=\"https:\/\/cms.core-way.de\/wp-content\/uploads\/2025\/08\/w-und-b-uneu.jpg\" alt=\"\" class=\"wp-image-3866\" srcset=\"https:\/\/cms.core-way.de\/wp-content\/uploads\/2025\/08\/w-und-b-uneu.jpg 495w, https:\/\/cms.core-way.de\/wp-content\/uploads\/2025\/08\/w-und-b-uneu-300x187.jpg 300w\" sizes=\"auto, (max-width: 495px) 100vw, 495px\" \/><\/figure>\n\n\n\n<p>The image shows where the inflammation in ulcerative colitis is located in the intestine. Image source: W&amp;B\/J\u00f6rg Neisel<\/p>\n\n\n\n<p>Further goals of Crohn's disease therapy are to achieve a <strong>steroid-free remission<\/strong> and the associated improvement in patients' living conditions. In addition, targeted therapy is intended to reduce the need for <strong>Hospitalization or operations <\/strong>be reduced. Another objective is to achieve and maintain a <strong>Remission<\/strong> in Crohn's disease. Remission is the period of the disease during which there are few or no symptoms.<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-39576e99\"><h2 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Schweregrade_der_Erkrankung_und_deren_Therapieansatze_bei_Morbus_Crohn\"><\/span><strong>Severity of the disease and its therapy<\/strong>approaches for Crohn's disease<span class=\"ez-toc-section-end\"><\/span><\/h2><\/div>\n\n\n\n<p>Crohn's disease occurs in various degrees of severity. A distinction is made between a mild to moderate flare-up, a moderate to severe flare-up and possible fistula formation.&nbsp;<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-fa1f66cf\"><h2 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Das_beeinflusst_deinen_individuelle_Morbus_Crohn_Therapie\"><\/span><strong>This influences your individual Crohn's disease therapy:<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2><\/div>\n\n\n\n<p>Which therapy is used for the individual patient depends on various factors. In addition to the infestation pattern, these include the presence of diseases, the <strong>in connection with the CED disease<\/strong> stand. However, diseases that have no connection with the IBD diagnosis are also taken into account. In addition, the <strong>Age<\/strong>the <strong><a href=\"https:\/\/cms.core-way.de\/en\/this-diet-is-recommended-for-your-ced-according-to-the-ecco-guidelines-2025\/\">Nutritional status<\/a><\/strong> and the associated <strong>Deficiencies<\/strong> important parameters that are taken into account when deciding on a particular form of therapy.<\/p>\n\n\n\n<p>We will now briefly introduce you to the various therapies that can be used to treat Crohn's disease, depending on the severity of the flare-ups. However, always speak<strong> individual<\/strong> with your doctor to find out which <strong>Therapy for your disease progression<\/strong> comes into question. The overview of the forms of therapy <strong>none<\/strong> No claim to completeness.<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-b871fc47\"><h3 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Milder_Krankheitsschub\"><\/span><strong>Mild relapse<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3><\/div>\n\n\n\n<p>According to the S3 guideline, the active ingredient mesalazine may be considered for mild flare-ups. However, depending on the individual clinical picture, it is also possible that no medication will be prescribed.&nbsp;<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-c3946cc9\"><h3 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Therapieansatz_bei_Morbus_Crohn_mit_milden_bis_moderaten_Schuben\"><\/span><strong>Therapeutic approach for Crohn's disease with mild to moderate relapses <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3><\/div>\n\n\n\n<p>Budesonide is also used for Crohn's disease. This is used for mild to moderate relapses. The inflammation is mainly localized in the transition between the small and large intestine and in the large intestine on the right side.<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-c53e6bcb\"><h3 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Moderater_bis_hoher_Krankheitsschub\"><\/span><strong>Moderate to high disease severity<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3><\/div>\n\n\n\n<p>&nbsp;For moderate to severe episodes of the disease, the S3 guideline describes treatment with systemic steroids - especially if the inflammation is limited to the right colon area.&nbsp;<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-cfc9ffd6\"><h3 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Das_kannst_du_tun_bei_einem_Krankheitsschub_im_oberen_Magen-Darm-Trakt\"><\/span><strong>What you can do if you have a flare-up in the upper gastrointestinal tract <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3><\/div>\n\n\n\n<p>If Crohn's disease causes inflammation in the upper part of the gastrointestinal tract, i.e. the esophagus, stomach or upper small intestine are affected, the following active substances are used to reduce the flare-up and induce remission.<\/p>\n\n\n\n<p>One of these active substances is systemic steroids. According to the S3 guidelines, this form of therapy should be considered if the upper gastrointestinal tract is affected.  In the further course, treatment with biologics or TNF-alpha inhibitors can then be considered. It is best to talk to your doctor about this in order to <strong>Short bowel syndrome<\/strong>poor absorption of food in the intestine (<strong>Malabsorption<\/strong>) or operations.<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-100a76eb\"><h3 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Moderater_bis_hoher_Krankheitsschub-2\"><\/span><strong>Moderate to high disease severity<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3><\/div>\n\n\n\n<p>If steroids do not work in the treatment of a moderate to severe relapse and a remission does not occur within six months, this is a steroid-refractory course of Crohn's disease. According to the guideline, the use of biologics such as TNF-alpha inhibitors can be considered in refractory courses. Talk to your doctor about whether this form of therapy is suitable for you.   TNF-alpha inhibitors are used in such cases.<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-31bd9885\"><h3 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Therapieansatze_bei_Morbus_Crohn_mit_Fistelbildung\"><\/span><strong>Therapeutic approaches for Crohn's disease with fistula formation<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3><\/div>\n\n\n\n<p>If fistula formation occurs, there are various therapeutic options according to the S3 guideline. These include, for example, local preparations such as rectal foams or suppositories. Here too, your doctor will select the appropriate preparation. If fistula formation occurs, various remedies can be used to treat it. These can be rectal foams, rectal suppositories or enemas.<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-d858d559\"><h2 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Remissionserhalt\"><\/span><strong>Maintenance of remission<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2><\/div>\n\n\n\n<p>After successful relapse therapy, remission-preserving treatment should be carried out. The following treatment options are available for this:<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-7830a757\"><h3 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Das_beeinflusst_deine_Remission\"><\/span><strong>This influences your remission<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3><\/div>\n\n\n\n<p>Patients who are smokers should be encouraged to stop smoking, as according to the S3 guideline this is a <strong>Positive impact<\/strong> on the maintenance of remission. Passive smoking is also harmful and can impair remission maintenance. Both should therefore be avoided for longer remission maintenance.<\/p>\n\n\n\n<p>Whether medication also needs to be taken during remission depends on the severity of the relapses and also the <strong>Pre-therapy<\/strong> from. Essentially, however, the consensus according to the guideline is that remission-inducing drugs can be discontinued after a long period of clinically stable remission.&nbsp;<\/p>\n\n\n\n<p>However, if there is a steroid-dependent course or another risk factor, such as the patient's young age or extensive small bowel involvement, remission-preserving therapy is recommended once remission has been achieved. According to the S3 guideline, combination therapy with infliximab and thiopurines is recommended for patients at risk.<\/p>\n\n\n\n<p>For patients who have a steroid-dependent course, the active substance azathioprine\/6-mercaptopurine, for example, is used after the onset of remission. In this case, the active substance is strongly adapted to the previous therapy. Therefore, talk to your doctor about which active ingredient is best suited to your individual therapy plan for your IBD.&nbsp;&nbsp;<\/p>\n\n\n\n<p>In a nutshell, this means the following for patients diagnosed with Crohn's disease:<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-edc444d6\"><h3 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"_Remissionserhalt\"><\/span><strong>&nbsp;Maintenance of remission<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>After successful relapse therapy, a <strong>Remission-preserving treatment<\/strong> recommended, among others with:<br>\n<ul class=\"wp-block-list\">\n<li>Azathioprine, 6-mercaptopurine, methotrexate (MTX)<br><\/li>\n\n\n\n<li>Biologics: vedolizumab, ustekinumab, TNF-\u03b1 antibodies<br><\/li>\n\n\n\n<li>Upadacitinib, Risankizumab (newly included in the 2024 guideline)<br><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-cf94a103\"><h3 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Neue_Therapieansatze_bei_Morbus_Crohn\"><\/span><strong>New therapeutic approaches for Crohn's disease<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>JAK inhibitors<\/strong> (upadacitinib): for refractory courses or steroid intolerance<br><\/li>\n\n\n\n<li><strong>IL-23 antibodies<\/strong> (Risankizumab): also newly included<br><\/li>\n\n\n\n<li><strong>Microbiome therapies, stem cell therapy<\/strong>: only in studies<br><\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-ccc631bb\"><h3 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Therapiemoglichkeiten_in_der_Schwangerschaft\"><\/span><strong>Therapy options during pregnancy<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>According to the guideline <strong>TNF-\u03b1 antibodies, vedolizumab and ustekinumab<\/strong> can also be used during pregnancy.<br><\/li>\n\n\n\n<li><strong>Upadacitinib and methotrexate should be avoided<\/strong><strong><br><\/strong><\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-11b442bf\"><h2 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Fazit_%E2%80%93_Was_bedeutet_das_fur_dich_als_Patient_in\"><\/span><strong>Conclusion - What does this mean for you as a patient?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2><\/div>\n\n\n\n<p>Today, Crohn's disease therapy is more individualized than ever. The modern S3 guideline gives doctors clear recommendations, but also leaves room for personal needs, comorbidities and previous treatment experience. Be sure to talk to your specialist about which of the options is right for you.<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-0c585136\"><h2 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"_FAQ_%E2%80%93_Haufige_Fragen_zur_MC-Therapie\"><\/span><strong>&nbsp;FAQ - Frequently asked questions about MC therapy<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2><\/div>\n\n\n\n<p><strong>Can Crohn's disease be cured?<\/strong><strong><br><\/strong> No, not at the moment. The aim is to achieve long-term freedom from symptoms (remission).<\/p>\n\n\n\n<p><strong>What should I do if my medication doesn't help?<\/strong><strong><br><\/strong> There are now many active substances - if there is no response, the treatment can be adjusted individually.<\/p>\n\n\n\n<p><strong>Can I \"eat healthy\"?<\/strong><strong><br><\/strong> An anti-inflammatory diet can help - but it is no substitute for drug therapy.<\/p>\n\n\n\n<p><strong>How important is the early detection of relapses?<\/strong><strong><br><\/strong> Very important! The earlier it is treated, the better the chances of avoiding complications.<\/p>\n\n\n\n<div class=\"wp-block-uagb-advanced-heading uagb-block-f6f129bc\"><h2 class=\"uagb-heading-text\"><span class=\"ez-toc-section\" id=\"Quellen\"><\/span>Sources<span class=\"ez-toc-section-end\"><\/span><\/h2><\/div>\n\n\n\n<p>Sturm A, Atreya R, Bettenworth D, et al. Updated S3 guideline \"Diagnosis and treatment of Crohn's disease\" of the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) - Version 4.1. Z Gastroenterol 2024; 62: 1229-1318. DOI: 10.1055\/a-2309-6123.<\/p>\n\n\n\n<p>Lorenz P, Stallmach A, Sturm A, Lynen Jansen P. Guideline report of the updated S3 guideline \"Diagnostics and therapy of Crohn's disease\" of the DGVS. Z Gastroenterol 2024; 62: e531-e536. DOI: 10.1055\/a-2309-6204.<\/p>\n\n\n\n<p>DGVS (ed.). Supplementary material to \"Guideline report of the updated S3 guideline Diagnostics and therapy of Crohn's disease\". Z Gastroenterol 2024; 62 (Supplement): 1-35. DOI: 10.1055\/a-2309-6204 (Appendix 6).<\/p>","protected":false},"excerpt":{"rendered":"<p>The treatment of chronic inflammatory bowel diseases is difficult and depends on the severity of the disease. 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